Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching Skinner JJ; Wood S; Shorter J; Englander SW; Black BEJ Cell Biol 2008[Dec]; 183 (5): 761-8The metamorphic Mad2 protein acts as a molecular switch in the checkpoint mechanism that monitors proper chromosome attachment to spindle microtubules during cell division. The remarkably slow spontaneous rate of Mad2 switching between its checkpoint inactive and active forms is catalyzed onto a physiologically relevant time scale by a self-self interaction between its two forms, culminating in a large pool of active Mad2. Recent structural, biochemical, and cell biological advances suggest that the catalyzed conversion of Mad2 requires a major structural rearrangement that transits through a partially unfolded intermediate.|Animals[MESH]|Calcium-Binding Proteins/*chemistry/*metabolism[MESH]|Catalysis[MESH]|Cell Cycle Proteins/*chemistry/*metabolism[MESH]|Humans[MESH]|Kinetics[MESH]|Mad2 Proteins[MESH]|Mitosis/*physiology[MESH]|Models, Molecular[MESH]|Nuclear Proteins/metabolism[MESH]|Prions/chemistry/metabolism[MESH]|Protein Conformation[MESH]|Protein Folding[MESH]|Protein Multimerization[MESH]|Repressor Proteins/*chemistry/*metabolism[MESH]|Spindle Apparatus/metabolism[MESH]|Structure-Activity Relationship[MESH] |
