Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Emerging pathways in genetic Parkinson s disease: Potential role of ceramide metabolism in Lewy body disease Bras J; Singleton A; Cookson MR; Hardy JFEBS J 2008[Dec]; 275 (23): 5767-73Heterozygous loss-of-function mutations at the glucosecerebrosidase locus have recently been shown to be a potent risk factor for Lewy body disease. Based on this observation, we have re-evaluated the likelihood that the different PARK loci (defined using clinical criteria for disease) may be misleading attempts to find common pathways to pathogenesis. Rather, we suggest, grouping the different loci which lead to different Lewy body disease may be more revealing. Doing this, we suggest that several of the genes involved in disparate Lewy body diseases impinge on ceramide metabolism and we suggest that this may be a common theme for pathogenesis.|Carrier Proteins/genetics/metabolism[MESH]|Ceramides/*metabolism[MESH]|Humans[MESH]|Intracellular Signaling Peptides and Proteins[MESH]|Lewy Bodies/metabolism[MESH]|Lewy Body Disease/genetics/metabolism/physiopathology[MESH]|Membrane Glycoproteins/genetics/metabolism[MESH]|Niemann-Pick C1 Protein[MESH]|Parkinson Disease/*genetics/metabolism/physiopathology[MESH]|Phosphotransferases/genetics/metabolism[MESH]|Serine C-Palmitoyltransferase/genetics/metabolism[MESH]|Signal Transduction/*genetics/physiology[MESH]|alpha-Synuclein/genetics/metabolism[MESH] |