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lüll High-density lipoprotein: does it have a dark side?Von Feldt JMArthritis Res Ther 2008[]; 10 (5): 121There are proven pleiotropic anti-atherogenic actions of high-density lipoprotein (HDL). However, in systemic inflammation, HDL can have pro-inflammatory properties that may contribute to accelerated atherosclerosis, likely mediated by a change in the structure of HDL to pro-inflammatory HDL (PiHDL). Validation of the technically challenging assay for PiHDL, and confirmation of an association of PiHDL in multiple populations with known risk for atherosclerosis will eventually provide a useful biomarker. Identification of PiHDL in patients with rheumatic disease may help identify patients at risk of accelerated atherosclerosis, and focus our therapeutic interventions.|Animals[MESH]|Atherosclerosis/etiology/metabolism[MESH]|Humans[MESH]|Inflammation/*metabolism[MESH]|Lipoproteins, HDL/*adverse effects/chemistry/metabolism[MESH] |