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Phospholipase A2 structure/function, mechanism, and signaling Burke JE; Dennis EAJ Lipid Res 2009[Apr]; 50 Suppl (Suppl): S237-42Tremendous advances in understanding the structure and function of the superfamily of phospholipase A2 (PLA2) enzymes has occurred in the twenty-first century. The superfamily includes 15 groups comprising four main types including the secreted sPLA2, cytosolic cPLA2, calcium-independent iPLA2, and platelet activating factor (PAF) acetyl hydrolase/oxidized lipid lipoprotein associated (Lp)PLA2. We review herein our current understanding of the structure and interaction with substrate phospholipids, which resides in membranes for a representative of each of these main types of PLA2. We will also briefly review the development of inhibitors of these enzymes and their roles in lipid signaling.|*Signal Transduction[MESH]|1-Alkyl-2-acetylglycerophosphocholine Esterase/metabolism[MESH]|Animals[MESH]|Calcium/metabolism[MESH]|Cytosol/enzymology[MESH]|Humans[MESH]|Lipid Metabolism[MESH]|Phospholipases A2/*chemistry/genetics/*metabolism[MESH] |
