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lüll Interstitial cells of Cajal in the gut--a gastroenterologist s point of view Negreanu LM; Assor P; Mateescu B; Cirstoiu CWorld J Gastroenterol 2008[Nov]; 14 (41): 6285-8Alterations of normal function of interstitial cells of Cajal (ICC) are reported in many intestinal disorders. Diagnosis of their involvement is rare (infrequent), but necessary to propose a specific treatment. This article reviews the place of ICC in the pathogenesis of achalasia, gastroesophageal reflux disease, infantile hypertrophic pyloric stenosis, chronic intestinal pseudo-obstruction and slow transit constipation. Moreover we discuss the role of the Cajal cells in the development of stromal tumors of the gastrointestinal tract.|*Biological Clocks[MESH]|*Gastroenterology[MESH]|*Gastrointestinal Motility[MESH]|Constipation/pathology/physiopathology[MESH]|Esophageal Achalasia/pathology/physiopathology[MESH]|Esophagus/pathology/physiopathology[MESH]|Gastroesophageal Reflux/pathology/physiopathology[MESH]|Gastrointestinal Diseases/*pathology/physiopathology[MESH]|Gastrointestinal Stromal Tumors/pathology/physiopathology[MESH]|Gastrointestinal Tract/*pathology/physiopathology[MESH]|Gastroparesis/pathology/physiopathology[MESH]|Humans[MESH]|Intestinal Pseudo-Obstruction/pathology/physiopathology[MESH]|Intestines/pathology/physiopathology[MESH]|Pyloric Stenosis, Hypertrophic/pathology/physiopathology[MESH]|Stomach/pathology/physiopathology[MESH] |