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How can genetic advances impact on experimental models of encapsulating peritoneal sclerosis?Summers AM; Hoff CM; Topley NPerit Dial Int 2008[Nov]; 28 Suppl 5 (ä): S16-20In this review we discuss how animal models have contributed to the understanding of pathological pathways that may be involved in the development of encapsulating peritoneal sclerosis. We review the various interventional procedures that, so far, have ameliorated disease progression in animals. Reviewing advancements in molecular biology and genetic technologies, we discuss how future experimental models may impact our understanding of the pathogenesis and treatment of this rare but complex disease.|*Animal Experimentation[MESH]|Animals[MESH]|Dialysis Solutions/pharmacology[MESH]|Genetic Predisposition to Disease[MESH]|Genetic Therapy[MESH]|Humans[MESH]|Peritoneal Dialysis/*adverse effects[MESH]|Peritoneum/drug effects/*pathology[MESH]|Sclerosis/genetics/pathology/therapy[MESH] |
