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lüll Pulmonary gas exchange in diving Moon RE; Cherry AD; Stolp BW; Camporesi EMJ Appl Physiol (1985) 2009[Feb]; 106 (2): 668-77Diving-related pulmonary effects are due mostly to increased gas density, immersion-related increase in pulmonary blood volume, and (usually) a higher inspired Po(2). Higher gas density produces an increase in airways resistance and work of breathing, and a reduced maximum breathing capacity. An additional mechanical load is due to immersion, which can impose a static transrespiratory pressure load as well as a decrease in pulmonary compliance. The combination of resistive and elastic loads is largely responsible for the reduction in ventilation during underwater exercise. Additionally, there is a density-related increase in dead space/tidal volume ratio (Vd/Vt), possibly due to impairment of intrapulmonary gas phase diffusion and distribution of ventilation. The net result of relative hypoventilation and increased Vd/Vt is hypercapnia. The effect of high inspired Po(2) and inert gas narcosis on respiratory drive appear to be minimal. Exchange of oxygen by the lung is not impaired, at least up to a gas density of 25 g/l. There are few effects of pressure per se, other than a reduction in the P50 of hemoglobin, probably due to either a conformational change or an effect of inert gas binding.|*Pulmonary Ventilation[MESH]|Airway Resistance[MESH]|Animals[MESH]|Diffusion[MESH]|Diving/*adverse effects[MESH]|Hemoglobins/metabolism[MESH]|Humans[MESH]|Hypercapnia/etiology/metabolism/*physiopathology[MESH]|Hyperoxia/etiology/metabolism/*physiopathology[MESH]|Lung Compliance[MESH]|Lung/blood supply/*physiopathology[MESH]|Oxygen/blood[MESH]|Pulmonary Circulation[MESH]|Pulmonary Edema/etiology/physiopathology[MESH]|Respiratory Dead Space[MESH]|Respiratory Mechanics[MESH]|Tidal Volume[MESH]|Ventilation-Perfusion Ratio[MESH]|Work of Breathing[MESH] |