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lüll Cdk5 and the non-catalytic arrest of the neuronal cell cycle Zhang J; Herrup KCell Cycle 2008[Nov]; 7 (22): 3487-90Cyclin-dependent kinase 5 (Cdk5) is a nontraditional Cdk that is primarily active in postmitotic neurons. An important core function of Cdk5 involves regulating the migration and maturation of embryonic post-mitotic neurons. These developmental roles are dependent on its kinase activity. Initially, there was little evidence indicating a role for Cdk5 in normal cell cycle regulation. Recent data from our lab, however, suggest that Cdk5 plays a crucial role as a cell cycle suppressor in normal post-mitotic neurons and neuronal cell lines. It performs this foundation in a kinase independent manner. Cdk5 normally found in both nucleus and cytoplasm, but it exits the nucleus in neurons risk to death in an AD patient's brain. The shift in sub-cellular location is accompanied by cell cycle re-entry and neuronal death. This "new" function of Cdk5 raises cautions in the design of Cdk5-directed drugs for the therapy of neurodegenerative diseases.|*Cell Cycle[MESH]|Animals[MESH]|Cyclin-Dependent Kinase 5/*physiology[MESH]|Humans[MESH]|Neurodegenerative Diseases/etiology[MESH]|Neurons/*cytology/pathology[MESH] |