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lüll Epigenetics: poly(ADP-ribosyl)ation of PARP-1 regulates genomic methylation patterns Caiafa P; Guastafierro T; Zampieri MFASEB J 2009[Mar]; 23 (3): 672-8In the postgenome era, attention is being focused on those epigenetic modifications that modulate chromatin structure to guarantee that information present on DNA is read correctly and at the most appropriate time to meet cellular requirements. Data reviewed show that along the chain of events that induce DNA methylation-dependent chromatin condensation/decondensation, a postsynthetic modification other than histone acetylation, phosphorylation, and methylation--namely poly(ADP-ribosyl)ation (PARylation)--participates in the establishment and maintenance of a genome methylation pattern. We hypothesize that the right nuclear balance between unmodified and PARylated poly(ADP-ribose) polymerase 1 (PARP-1), which depends on the dynamics of PARPs/PARG activity, is key to maintaining genomic methylation pattern. According to our data, decreased or increased levels of PARylated PARP-1 are responsible for diffuse hypermethylation or hypomethylation of DNA, respectively. In our model, polymers present on PARP-1 interact noncovalently with DNA methyltransferase 1 (Dnmt1), preventing its enzymatic activity. In the absence of PARylated PARP-1, Dnmt1 is free to methylate DNA; if, in contrast, high levels of PARylated PARP-1 persist, Dnmt1 will be stably inhibited, preventing DNA methylation.|*Epigenesis, Genetic[MESH]|DNA Methylation[MESH]|Genomics[MESH]|Poly Adenosine Diphosphate Ribose/*metabolism[MESH]|Poly(ADP-ribose) Polymerases/*genetics/*metabolism[MESH]|Proteins/*metabolism[MESH]|Transcription, Genetic[MESH] |