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Nutritional regulation of glucagon-like peptide-1 secretion Tolhurst G; Reimann F; Gribble FMJ Physiol 2009[Jan]; 587 (1): 27-32Glucagon-like peptide-1 (GLP-1), released from L-cells in the intestinal epithelium, plays an important role in postprandial glucose homeostasis and appetite control. Following the recent therapeutic successes of antidiabetic drugs aimed at either mimicking GLP-1 or preventing its degradation, attention is now turning towards the L-cell, and addressing whether it would be both possible and beneficial to stimulate the endogenous release of GLP-1 in vivo. Understanding the mechanisms underlying GLP-1 release from L-cells is key to this type of approach, and the use of cell line models has led to the identification of a variety of pathways that may underlie the physiological responses of L-cells to food ingestion. This review focuses on our current understanding of the signalling mechanisms that underlie L-cell nutrient responsiveness.|Animals[MESH]|Eating/physiology[MESH]|Enteroendocrine Cells/drug effects/metabolism/physiology[MESH]|Glucagon-Like Peptide 1/*metabolism[MESH]|Glucose/administration & dosage/metabolism[MESH]|Glutamate Plasma Membrane Transport Proteins/metabolism[MESH]|Humans[MESH]|KATP Channels/metabolism[MESH]|Models, Biological[MESH]|Signal Transduction[MESH]|Taste Buds/physiology[MESH] |
