Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease Kumar JPCell Mol Life Sci 2009[Feb]; 66 (4): 565-83The sine oculis homeobox (SIX) protein family is a group of evolutionarily conserved transcription factors that are found in diverse organisms that range from flatworms to humans. These factors are expressed within, and play pivotal developmental roles in, cell populations that give rise to the head, retina, ear, nose, brain, kidney, muscle and gonads. Mutations within the fly and mammalian versions of these genes have adverse consequences on the development of these organs/tissues. Several SIX proteins have been shown to directly influence the cell cycle and are present at elevated levels during tumorigenesis and within several cancers. This review aims to highlight aspects of (1) the evolutionary history of the SIX family; (2) the structural differences and similarities amongst the different SIX proteins; (3) the role that these genes play in retinal development; and (4) the influence that these proteins have on cell proliferation and growth.|*Homeodomain Proteins/genetics/metabolism[MESH]|*Protein Isoforms/genetics/metabolism[MESH]|*Transcription Factors/genetics/metabolism[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Cell Cycle/physiology[MESH]|Evolution, Molecular[MESH]|Gene Duplication[MESH]|Humans[MESH]|Molecular Sequence Data[MESH]|Morphogenesis/physiology[MESH]|Neoplasms/genetics/metabolism[MESH]|Photoreceptor Cells, Invertebrate/physiology[MESH]|Retina/anatomy & histology/physiology[MESH]|Sequence Alignment[MESH]|Signal Transduction/physiology[MESH] |