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To beta or not to beta: canonical beta-catenin signaling pathway and ovarian development Tevosian SG; Manuylov NLDev Dyn 2008[Dec]; 237 (12): 3672-80The mammalian embryonic gonad is a unique organ primordium in that it can adopt two different developmental fates-namely, differentiate as either a testis or an ovary-with dramatic consequences for an individual. While a molecular cascade culminating in testis development is well characterized, the ovarian pathways still remain enigmatic. The canonical Wnt/beta-catenin signaling implements a conserved mechanism of regulating gene expression that is integral to development of all metazoans. In this review, we summarize the recent evidence that suggests a central role for this signaling pathway in the development of the mammalian female.|*Signal Transduction[MESH]|Animals[MESH]|Female[MESH]|Gene Expression Regulation, Developmental[MESH]|Humans[MESH]|Ovary/*embryology/*metabolism[MESH]|Phenotype[MESH]|Wnt Proteins/genetics/metabolism[MESH]|beta Catenin/genetics/*metabolism[MESH] |
