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lüll X-chromosome inactivation: the molecular basis of silencing Panning BJ Biol 2008[Oct]; 7 (8): 30X-chromosome inactivation occurs randomly for one of the two X chromosomes in female cells during development. Inactivation occurs when RNA transcribed from the Xist gene on the X chromosome from which it is expressed spreads to coat the whole X chromosome. In the first issue of Epigenetics and Chromatin, Nesterova and colleagues investigate the role of the RNA interference pathway enzyme Dicer in DNA methylation of the Xist promoter.|*Genes, X-Linked[MESH]|Animals[MESH]|DEAD-box RNA Helicases/genetics/metabolism[MESH]|Embryo, Mammalian/*cytology/physiology[MESH]|Embryonic Stem Cells/cytology/metabolism[MESH]|Endoribonucleases/genetics/metabolism[MESH]|Female[MESH]|Gene Silencing/*physiology[MESH]|Male[MESH]|Mice[MESH]|Mutation[MESH]|RNA Interference[MESH]|Ribonuclease III[MESH]|X Chromosome Inactivation/*genetics[MESH] |