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lüll Immune regulation of bone loss by Th17 cells Adamopoulos IE; Bowman EPArthritis Res Ther 2008[]; 10 (5): 225A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.|Animals[MESH]|Arthritis, Rheumatoid/*immunology/pathology[MESH]|Bone Resorption/*immunology/pathology[MESH]|Cell Differentiation[MESH]|Humans[MESH]|Osteoclasts/cytology[MESH]|T-Lymphocyte Subsets/*immunology[MESH]|T-Lymphocytes, Helper-Inducer/*immunology[MESH] |