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Duchenne muscular dystrophy Yiu EM; Kornberg AJNeurol India 2008[Jul]; 56 (3): 236-47Duchenne muscular dystrophy (DMD), an X-linked disorder, is the most common muscular dystrophy in children, presenting in early childhood and characterized by proximal muscle weakness and calf hypertrophy in affected boys. Patients usually become wheelchair-bound by the age of 12 years, and die of cardiorespiratory complications in their late teens to early twenties. Advances in the management of DMD, including treatment with corticosteroids and the use of intermittent positive pressure ventilation have provided improvements in function, ambulation, quality of life and life expectancy, although novel therapies still aim to provide a cure for this devastating disorder. The clinical features, investigations, and management of DMD are reviewed, as well as the latest in some of the novel therapies.|*Muscular Dystrophy, Duchenne/genetics/physiopathology/therapy[MESH]|Electromyography[MESH]|Humans[MESH]|Molecular Biology[MESH] |
