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lüll The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients Ward NS; Casserly B; Ayala AClin Chest Med 2008[Dec]; 29 (4): 617-25, viiiLike the systemic inflammatory response syndrome (SIRS), the compensatory anti-inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to severe infection or injury. The difference is that while SIRS is a proinflammatory response tasked with killing infectious organisms through activation of the immune system, CARS is a global deactivation of the immune system tasked with restoring homeostasis. Much research now suggests that the timing and relative magnitude of this response have a profound impact on patient outcomes.|Animals[MESH]|Antigen-Presenting Cells/immunology[MESH]|Apoptosis/immunology[MESH]|Clonal Anergy/immunology[MESH]|Critical Illness[MESH]|Down-Regulation/immunology[MESH]|HLA-DR Antigens/blood[MESH]|Homeostasis/*immunology[MESH]|Humans[MESH]|Immune Tolerance/*immunology[MESH]|Immunity, Cellular/*immunology[MESH]|Inflammation Mediators/*blood[MESH]|Lymphocytes/immunology[MESH]|Monocytes/immunology[MESH]|Sepsis/*immunology[MESH]|Suppressor Factors, Immunologic/*blood[MESH]|Systemic Inflammatory Response Syndrome/*immunology[MESH] |