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Immunoglobulin expression and its biological significance in cancer cells Hu D; Zheng H; Liu H; Li M; Ren W; Liao W; Duan Z; Li L; Cao YCell Mol Immunol 2008[Oct]; 5 (5): 319-24It is generally believed that the expression of a gene is restricted "within the right place and at the right time". This principle has long been considered applicable as well to the expression of immunoglobulin (Ig) lymphocytes of B cell lineage. However, increasing evidence has shown Ig "paradoxically" expressed in malignant tumors of epithelial origin. We reviewed the recent progress in the study of cancer-derived Ig, and also discussed its mechanisms and possible functions, trying to arouse interest and attention to those working in the field of immunology and oncology.|B-Lymphocytes/*immunology/metabolism[MESH]|Cell Lineage/immunology[MESH]|Complementarity Determining Regions[MESH]|Humans[MESH]|Immunoglobulin Class Switching[MESH]|Immunoglobulins/biosynthesis/*immunology[MESH]|Neoplasms/*immunology/metabolism[MESH]|VDJ Exons[MESH] |
