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l�ll Gammadelta T-cells: potential regulators of the post-burn inflammatory response Schwacha MGBurns 2009[May]; 35 (3): 318-26Severe burn induces an immunopathological response that contributes to the development of a systemic inflammatory response (SIRS) and subsequent multiple organ failure. While, multiple immune cells type (T-cells, macrophages, neutrophils) are involved in this response, recent evidence suggests that a unique T-cell subset, gammadelta T-cells are central in the response to injury. While gammadelta T-cells represent only a small percentage of the total T-cell population, they display specific functional characteristics that uniquely position them in the immune/inflammatory axis to influence a number of important aspects of the body's response to burn. This review will focus on the potential regulator role of gammadelta T-cells in immunopathological response following burn and thereby their potential as therapeutic targets for affecting inflammation and healing.|Animals[MESH]|Biomarkers/metabolism[MESH]|Burns/*immunology/therapy[MESH]|Humans[MESH]|Immunity, Cellular[MESH]|Immunotherapy/methods[MESH]|Inflammation/immunology[MESH]|Lymphocyte Activation/immunology[MESH]|Mice[MESH]|Skin/immunology[MESH]|T-Lymphocyte Subsets/*physiology/transplantation[MESH]|T-Lymphocytes/immunology[MESH]|Wound Healing/*immunology[MESH] |