Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Perioperative hemostatic management of patients treated with vitamin K antagonists Levy JH; Tanaka KA; Dietrich WAnesthesiology 2008[Nov]; 109 (5): 918-26Clinicians, including anesthesiologists, surgeons, and intensivists, are frequently called on to correct coagulopathy in patients receiving oral anticoagulation therapy. Before elective surgery, anticoagulation reversal may be undertaken over several days by discontinuing warfarin or vitamin K treatment, but rapid correction is required in an emergency. European and American guidelines recommend prothrombin complex concentrates (PCCs) for anticoagulation reversal in patients with life-threatening bleeding and an increased international normalized ratio. Compared with human fresh frozen plasma, PCCs provide quicker correction of the international normalized ratio and improved bleeding control. Although there are historic concerns regarding potential infectious and thrombotic risks with PCCs, current PCC formulations are much improved. Recombinant activated factor VII is a potential alternative to PCCs, but preclinical comparisons suggest that PCCs are more effective in correcting coagulopathy. Although many patients who require rapid reversal of warfarin are currently treated with fresh frozen plasma, PCCs should be considered as an alternative therapy.|Blood Coagulation Factors/pharmacology/therapeutic use[MESH]|Blood Coagulation/drug effects/physiology[MESH]|Blood Loss, Surgical/physiopathology/prevention & control[MESH]|Disease Management[MESH]|Hemostatics/pharmacology/*therapeutic use[MESH]|Humans[MESH]|International Normalized Ratio/methods[MESH]|Perioperative Care/*methods[MESH]|Vitamin K/adverse effects/*antagonists & inhibitors[MESH]|Warfarin/adverse effects/antagonists & inhibitors[MESH] |