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Total synthesis and development of bioactive natural products Tatsuta KProc Jpn Acad Ser B Phys Biol Sci 2008[]; 84 (4): 87-106The first total synthesis and development of a variety of bioactive natural products have been accomplished by using carbohydrates as a chiral source. In addition, practically useful intermediates have been created, analogs of natural products have been prepared, their structure-activity relationships studied, and the large-scale preparations of medicinally useful compounds established. The key target molecules have been the "Big Four" antibiotics (macrolides, aminoglycosides, beta-lactams and tetracyclines), pyranonaphthoquinone antibiotics, glycosidase inhibitors, and a side-chain of cephem antibiotics.|Anti-Infective Agents/chemical synthesis/pharmacology[MESH]|Biological Products/*chemical synthesis/*pharmacology[MESH]|Molecular Structure[MESH]|Structure-Activity Relationship[MESH] |
