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lüll Macrophages as APC and the dendritic cell myth Hume DAJ Immunol 2008[Nov]; 181 (9): 5829-35Dendritic cells have been considered an immune cell type that is specialized for the presentation of Ag to naive T cells. Considerable effort has been applied to separate their lineage, pathways of differentiation, and effectiveness in Ag presentation from those of macrophages. This review summarizes evidence that dendritic cells are a part of the mononuclear phagocyte system and are derived from a common precursor, responsive to the same growth factors (including CSF-1), express the same surface markers (including CD11c), and have no unique adaptation for Ag presentation that is not shared by other macrophages.|Animals[MESH]|Antigen-Presenting Cells/*cytology/*immunology/metabolism[MESH]|Biomarkers/metabolism[MESH]|Cell Differentiation/genetics/immunology[MESH]|Cell Lineage/genetics/immunology[MESH]|Dendritic Cells/*cytology/*immunology/metabolism[MESH]|Humans[MESH]|Macrophages/*cytology/*immunology/metabolism[MESH]|Mice[MESH] |