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lüll Chest radiographic and CT manifestations of chronic granulomatous disease in adults Godoy MC; Vos PM; Cooperberg PL; Lydell CP; Phillips P; Muller NLAJR Am J Roentgenol 2008[Nov]; 191 (5): 1570-5OBJECTIVE: The purpose of this study was to describe the thoracic radiologic findings of chronic granulomatous disease in adults. MATERIALS AND METHODS: We retrospectively analyzed the chest radiographic and CT findings in four adults with chronic granulomatous disease during five episodes of lower respiratory tract infection. RESULTS: Chest radiographic findings included areas of consolidation (60%), diffuse reticulonodular opacities (40%), pleural effusion (20%), and pulmonary artery enlargement (20%). CT findings included areas of consolidation (60%), pulmonary nodules in a random distribution (60%), centrilobular nodules (60%), tree-in-bud opacities (40%), areas of scarring and traction bronchiectasis (100%), emphysematous changes (75%), areas of decreased attenuation and vascularity associated with air trapping on expiratory CT (50%), mediastinal and/or hilar lymphadenopathy (60%), pulmonary artery enlargement (50%), and pleural effusion (20%). Areas of consolidation and nodules were the most prominent findings and at histologic examination were found to be associated with infection or granulomatous inflammation. CONCLUSION: The pulmonary radiologic findings of chronic granulomatous disease include consolidation, nodules, areas of scarring, traction bronchiectasis, emphysema, air trapping, mediastinal and hilar lymphadenopathy, pulmonary artery enlargement, and pleural effusion.|Adult[MESH]|Female[MESH]|Granulomatous Disease, Chronic/*diagnostic imaging[MESH]|Humans[MESH]|Male[MESH]|Pneumonia, Bacterial/*diagnostic imaging[MESH]|Radiography, Thoracic/*methods[MESH]|Tomography, X-Ray Computed/*methods[MESH] |