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Update on antiphospholipid syndrome Lockshin MDBull NYU Hosp Jt Dis 2008[]; 66 (3): 195-7This review addresses new clinical issues (revealed at the 2006 Sydney update of the 1999 Sapporo Classification criteria; cardiac, renal, and multiple sclerosis-like disease; catastrophic syndrome), mechanisms of action of antiphospholipid antibody (very likely complement mediated), current therapies (moderate dose warfarin recommended for prophylaxis, aspirin not recommended for primary prophylaxis), and potential new therapies.|*Antiphospholipid Syndrome/blood/complications/drug therapy/immunology[MESH]|*Thrombosis/blood/immunology/prevention & control[MESH]|Antibodies, Antiphospholipid/blood[MESH]|Anticoagulants/therapeutic use[MESH]|Aspirin/therapeutic use[MESH]|Blood Coagulation[MESH]|Complement System Proteins/metabolism[MESH]|Humans[MESH]|Platelet Aggregation Inhibitors/therapeutic use[MESH]|Warfarin/therapeutic use[MESH] |
