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lüll Peptide-based probes for cancer imaging Reubi JC; Maecke HRJ Nucl Med 2008[Nov]; 49 (11): 1735-8Receptors for regulatory peptides are overexpressed in a variety of human cancers. They represent the molecular basis for in vivo imaging with radiolabeled peptide probes. Somatostatin-derived tracers, designed to image the sst2-overexpressing neuroendocrine tumors, have enjoyed almost 2 decades of successful development and extensive clinical applications. More recent developments include second- and third-generation somatostatin analogs, with a broader receptor subtype profile or with antagonistic properties. Emerging tracers for other peptide receptors, including cholecystokinin/gastrin and GLP-1 analogs for neuroendocrine tumors, bombesin and neuropeptide-Y analogs for prostate or breast cancers, or Arg-Gly-Asp peptides for neoangiogenesis labeling, are also in current development. Application fields include both SPECT/CT and PET/CT.|*Peptides/chemistry[MESH]|Humans[MESH]|Neoplasms/*diagnosis/diagnostic imaging/metabolism[MESH]|Neuroendocrine Tumors/diagnosis/diagnostic imaging/metabolism[MESH]|Radioisotopes[MESH]|Radionuclide Imaging[MESH]|Somatostatin/analogs & derivatives[MESH]|Staining and Labeling/*methods[MESH] |