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Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer Boutros T; Chevet E; Metrakos PPharmacol Rev 2008[Sep]; 60 (3): 261-310Mitogen-activated protein kinase dual-specificity phosphatase-1 (also called MKP-1, DUSP1, ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine dual-specificity phosphatases, one of more than 100 protein tyrosine phosphatases. It was first identified approximately 20 years ago, and since that time extensive investigations into both mkp-1 mRNA and protein regulation and function in different cells, tissues, and organs have been conducted. However, no general review on the topic of MKP-1 exists. As the subject matter pertaining to MKP-1 encompasses many branches of the biomedical field, we focus on the role of this protein in cancer development and progression, highlighting the potential role of the mitogen-activated protein kinase (MAPK) family. Section II of this article elucidates the MAPK family cross-talk. Section III reviews the structure of the mkp-1 encoding gene, and the known mechanisms regulating the expression and activity of the protein. Section IV is an overview of the MAPK-specific dual-specificity phosphatases and their role in cancer. In sections V and VI, mkp-1 mRNA and protein are examined in relation to cancer biology, therapeutics, and clinical studies, including a discussion of the potential role of the MAPK family. We conclude by proposing an integrated scheme for MKP-1 and MAPK in cancer.|*Gene Expression Regulation[MESH]|Animals[MESH]|Cell Death/physiology[MESH]|Cell Proliferation[MESH]|Disease Progression[MESH]|Dual Specificity Phosphatase 1/genetics/*metabolism[MESH]|Humans[MESH]|Mitogen-Activated Protein Kinases/genetics/*metabolism[MESH]|Neoplasms/physiopathology[MESH]|RNA, Messenger/metabolism[MESH]|Signal Transduction[MESH] |
