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lüll Metabolic syndrome: from epidemiology to systems biology Lusis AJ; Attie AD; Reue KNat Rev Genet 2008[Nov]; 9 (11): 819-30Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and promote the development of cardiovascular disease (CVD) and diabetes. Recent genome-wide association studies have identified several novel susceptibility genes for MetSyn traits, and studies in rodent models have provided important molecular insights. However, as yet, only a small fraction of the genetic component is known. Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn.|*Genetic Variation[MESH]|Epigenesis, Genetic/*genetics[MESH]|Genetic Predisposition to Disease/*genetics[MESH]|Genomics/methods[MESH]|Humans[MESH]|Insulin Resistance/*genetics[MESH]|Metabolic Syndrome/*epidemiology/*genetics[MESH]|Risk Factors[MESH]|Sex Factors[MESH]|Systems Biology/*methods[MESH] |