Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Progress in periventricular leukomalacia Deng W; Pleasure J; Pleasure DArch Neurol 2008[Oct]; 65 (10): 1291-5Periventricular leukomalacia (PVL) is the predominant form of brain injury and the leading known cause of cerebral palsy and cognitive deficits in premature infants. The number of low-birth-weight infants who survive to demonstrate these neurologic deficts is increasing. Magnetic resonance imaging-based neuroimaging techniques provide greater diagnostic sensitivity for PVL than does head ultrasonography and often document the involvement of telencephalic gray matter and long tracts in addition to periventricular white matter. The neuropathologic hallmarks of PVL are microglial activation and focal and diffuse periventricular depletion of premyelinating oligodendroglia. Premyelinating oligodendroglia are highly vulnerable to death caused by glutamate, free radicals, and proinflammatory cytokines. Studies in animal models of PVL suggest that pharmacologic interventions that target these toxic molecules will be useful in diminishing the severity of PVL.|Animals[MESH]|Brain/*pathology/*physiopathology[MESH]|Encephalitis/etiology/pathology/physiopathology[MESH]|Female[MESH]|Gliosis/etiology/pathology/physiopathology[MESH]|Humans[MESH]|Infant, Newborn[MESH]|Leukomalacia, Periventricular/*diagnosis/metabolism/*physiopathology[MESH]|Magnetic Resonance Imaging/standards[MESH]|Microglia/metabolism/pathology[MESH]|Nerve Fibers, Myelinated/*pathology[MESH]|Neural Pathways/pathology/physiopathology[MESH]|Oligodendroglia/metabolism/*pathology[MESH]|Oxidative Stress/physiology[MESH]|Pregnancy[MESH] |