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lüll Levetiracetam for the treatment of co-occurring alcohol dependence and anxiety: case series and review Mariani JJ; Levin FRAm J Drug Alcohol Abuse 2008[]; 34 (6): 683-91OBJECTIVES: Alcohol dependence is frequently associated with anxiety disorders. The exact nature of the relationship between alcohol dependence and anxiety disorders is unknown, but emerging evidence suggests that in a majority of cases, the anxiety disorder is independent of the alcohol use disorder. There is pre-clinical and clinical evidence that levetiracetam, a newer generation anticonvulsant medication, may be efficacious in the treatment of co-occurring alcohol use and anxiety disorders. METHODS: In an open label clinical trial, three patients with alcohol dependence and a co-morbid anxiety disorder were treated with levetiracetam in doses up to 1500 mg twice daily for up to 8 weeks. RESULTS: All three participants reported reductions in alcohol consumption and anxiety symptoms during the study period. Levetiracetam was generally well tolerated. CONCLUSION: This study suggests that levetiracetam deserves further study in the treatment of alcohol dependence and co-occurring anxiety disorders.|Adult[MESH]|Alcohol Drinking/drug therapy[MESH]|Alcoholism/complications/*drug therapy[MESH]|Anxiety Disorders/complications/*drug therapy[MESH]|Diagnosis, Dual (Psychiatry)[MESH]|Female[MESH]|Humans[MESH]|Levetiracetam[MESH]|Male[MESH]|Middle Aged[MESH]|Nootropic Agents/adverse effects/*pharmacology[MESH]|Piracetam/adverse effects/*analogs & derivatives/pharmacology[MESH] |