Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Canonical and non-canonical JAK-STAT signaling Li WXTrends Cell Biol 2008[Nov]; 18 (11): 545-51Aberrant activation of the JAK-STAT pathway has been implicated in many human cancers. It has widely been assumed that the effects of STAT activation are mediated by direct transcriptional induction of STAT target genes. However, recent findings in Drosophila have identified a non-canonical mode of JAK-STAT signaling, which directly controls heterochromatin stability. This indicates that the JAK-STAT pathway also controls cellular epigenetic status, which affects expression of genes beyond those under direct STAT transcriptional control. Given the evolutionary conservation of the canonical pathway among different species, the non-canonical mode of JAK-STAT signaling might also operate in vertebrates. In this review, canonical versus non-canonical JAK-STAT signaling and the implications for gene regulation and cancer formation are discussed.|*Signal Transduction[MESH]|Animals[MESH]|Blood Cells/cytology/metabolism[MESH]|Cell Proliferation[MESH]|Chromobox Protein Homolog 5[MESH]|Chromosomal Proteins, Non-Histone/*metabolism[MESH]|Drosophila Proteins/*metabolism[MESH]|Drosophila/metabolism[MESH]|Epigenesis, Genetic[MESH]|Heterochromatin/metabolism[MESH]|Humans[MESH]|Janus Kinases/*metabolism[MESH]|Neoplasms/metabolism[MESH]|STAT Transcription Factors/*metabolism[MESH] |
