Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Regulation of potassium (K) handling in the renal collecting duct Wang WH; Giebisch GPflugers Arch 2009[May]; 458 (1): 157-68This review provides an overview of the molecular mechanisms of K transport in the mammalian connecting tubule (CNT) and cortical collecting duct (CCD), both nephron segments responsible for the regulation of renal K secretion. Aldosterone and dietary K intake are two of the most important factors regulating K secretion in the CNT and CCD. Recently, angiotensin II (AngII) has also been shown to play a role in the regulation of K secretion. In addition, genetic and molecular biological approaches have further identified new mechanisms by which aldosterone and dietary K intake regulate K transport. Thus, the interaction between serum-glucocorticoid-induced kinase 1 (SGK1) and with-no-lysine kinase 4 (WNK4) plays a significant role in mediating the effect of aldosterone on ROMK (Kir1.1), an important apical K channel modulating K secretion. Recent evidence suggests that WNK1, mitogen-activated protein kinases such as P38, ERK, and Src family protein tyrosine kinase are involved in mediating the effect of low K intake on apical K secretory channels.|Aldosterone/physiology[MESH]|Angiotensin II/physiology[MESH]|Animals[MESH]|Extracellular Signal-Regulated MAP Kinases/physiology[MESH]|Gastrointestinal Hormones/physiology[MESH]|Immediate-Early Proteins/metabolism[MESH]|Kidney Tubules, Collecting/drug effects/*metabolism[MESH]|Natriuretic Peptides/physiology[MESH]|Potassium Channels, Inwardly Rectifying/physiology[MESH]|Potassium, Dietary/*pharmacology[MESH]|Potassium/*metabolism[MESH]|Protein Serine-Threonine Kinases/metabolism/physiology[MESH]|p38 Mitogen-Activated Protein Kinases/physiology[MESH]|src-Family Kinases/physiology[MESH] |