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lüll Deconstructing meiosis one kinase at a time: polo pushes past pachytene Hollingsworth NMGenes Dev 2008[Oct]; 22 (19): 2596-600The transition from pachytene to Meiosis I is a key regulatory point in yeast meiosis. This transition requires Ndt80, a transcription factor that commits cells to complete meiosis by expression of a diverse set of genes. In this issue of Genes & Development, Sourirajan and Lichten (2627-2632) report that CDC5, an NDT80-regulated gene encoding yeast polo-like kinase, is sufficient for Holliday junction resolution and exit from pachytene. Determining the meiotic targets of Cdc5 therefore provides a new approach for identifying a eukaryotic Holliday resolvase.|Cell Cycle Proteins/genetics/physiology[MESH]|Chromosomes, Fungal/genetics/ultrastructure[MESH]|DNA-Binding Proteins/genetics/physiology[MESH]|Genes, Fungal[MESH]|Meiosis/*genetics/*physiology[MESH]|Models, Biological[MESH]|Pachytene Stage/*genetics/*physiology[MESH]|Protein Kinases/*genetics/*physiology[MESH]|Protein Serine-Threonine Kinases[MESH]|Saccharomyces cerevisiae Proteins/genetics/physiology[MESH]|Saccharomyces cerevisiae/cytology/genetics/physiology[MESH]|Transcription Factors/genetics/physiology[MESH] |