Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Amplification mechanisms for the enhancement of antigen-mediated mast cell activation Gilfillan AM; Peavy RD; Metcalfe DDImmunol Res 2009[]; 43 (1-3): 15-24Activation of mast cells in the allergic inflammatory response occurs via the high affinity receptor for IgE (FcepsilonRI) following receptor aggregation induced by antigen-mediated cross-linking of IgE-occupied FcepsilonRI. Recent observations suggest this response is profoundly influenced by other factors that reduce the threshold for, and increase the extent of, mast cell activation. For example, under experimental conditions, cell surface receptors such as KIT and specific G protein-coupled receptors synergistically enhance FcepsilonRI-mediated mast cell degranulation and cytokine production. Activating mutations in critical signaling molecules may also contribute to such responses. In this review, we describe our research exploring the mechanisms regulating these synergistic interactions and, furthermore, discuss the relevance of our observations in the context of clinical considerations.|Adaptor Proteins, Signal Transducing/immunology/metabolism[MESH]|Animals[MESH]|Cell Degranulation/*immunology[MESH]|Humans[MESH]|Mast Cells/*immunology/metabolism[MESH]|Phosphatidylinositol 3-Kinases/immunology/metabolism[MESH]|Receptors, G-Protein-Coupled/*immunology/metabolism[MESH]|Receptors, IgE/*immunology/metabolism[MESH]|Signal Transduction/immunology[MESH]|Stem Cell Factor/*immunology/metabolism[MESH] |