Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18827717&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Brain imaging in pediatric obsessive-compulsive disorder MacMaster FP; O'Neill J; Rosenberg DRJ Am Acad Child Adolesc Psychiatry 2008[Nov]; 47 (11): 1262-72OBJECTIVE: To review progress in understanding pediatric obsessive-compulsive disorder (OCD). The focus is on the frontal-striatal-thalamic model of OCD, neurobiological and genetic studies of the disorder, and their influence on recent advances in treatment. METHOD: Computerized literature searches were conducted with the key words "obsessive-compulsive disorder" in conjunction with "pediatric," "genetics," and "imaging." RESULTS: Neuroimaging studies find evidence to support the frontal-striatal-thalamic model. Genetic and neurochemical studies also implicate glutamate in the pathological finding of OCD. This has led to the application of glutamate-modulating agents to treat OCD. CONCLUSIONS: Studies of pediatric OCD have led to a refined frontal-striatal-thalamic model of pathogenesis and are having an evidence-based impact on treatment. Despite this progress, fully explanatory models are still needed that would allow for accurate prognosis and the development of targeted and efficacious treatments.|*Image Processing, Computer-Assisted[MESH]|*Magnetic Resonance Imaging[MESH]|Adolescent[MESH]|Adult[MESH]|Basal Ganglia/pathology/physiopathology[MESH]|Brain/pathology/*physiopathology[MESH]|Child[MESH]|Corpus Callosum/pathology/physiopathology[MESH]|Corpus Striatum/pathology/physiopathology[MESH]|Frontal Lobe/pathology/physiopathology[MESH]|Glutamic Acid/metabolism[MESH]|Gyrus Cinguli/pathology/physiopathology[MESH]|Humans[MESH]|Nerve Net/pathology/physiopathology[MESH]|Obsessive-Compulsive Disorder/diagnosis/drug therapy/*physiopathology/psychology[MESH]|Organ Size/physiology[MESH]|Thalamus/pathology/physiopathology[MESH] |
