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Liver transplantation for hepatitis B: what is the best hepatitis B immune globulin/antiviral regimen?Angus PW; Patterson SJLiver Transpl 2008[Oct]; 14 Suppl 2 (ä): S15-221. Prophylaxis using the combination of lamivudine and high-dose intravenous hepatitis B immunoglobulin (approximately 10,000 IU monthly) reduces the long-term risk of recurrence of hepatitis B in hepatitis B surface antigen-positive transplant recipients to 5% to 10%. However, this therapy is expensive and inconvenient for patients. 2. Recent studies have shown that similar results can be obtained, at far less cost, with much lower doses of intramuscular hepatitis B immune globulin (400-800 IU monthly) in combination with pretransplant and posttransplant lamivudine therapy. 3. The development of lamivudine resistance pre-transplant can lead to hepatic decompensation and increases the risk of posttransplant recurrence in patients receiving hepatitis B immune globulin/lamivudine prophylaxis. Newer nucleos(t)ide analogues with lower resistance rates such as entecavir, adefovir, and tenofovir should therefore replace lamivudine in hepatitis B prophylaxis. 4. Combination therapy with these newer agents and low-dose intramuscular hepatitis B immune globulin is likely to be the most cost effective hepatitis B immune globulin-containing regimen for the prevention of hepatitis B recurrence post-transplant. 5. Some form of hepatitis B virus prophylaxis needs be continued indefinitely post-transplant. However, the use of antivirals with very low rates of drug resistance will make it possible to stop hepatitis B immune globulin therapy in many patients currently receiving hepatitis B immune globulin/nucleos(t)ide combination therapy.|*Liver Transplantation[MESH]|Antiviral Agents/*administration & dosage[MESH]|Drug Therapy, Combination[MESH]|Hepatitis B/drug therapy/*surgery[MESH]|Humans[MESH]|Immunoglobulins, Intravenous/*administration & dosage[MESH]|Injections, Intramuscular[MESH]|Lamivudine/*administration & dosage[MESH] |
