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lüll MECP2 genomic structure and function: insights from ENCODE Singh J; Saxena A; Christodoulou J; Ravine DNucleic Acids Res 2008[Nov]; 36 (19): 6035-47MECP2, a relatively small gene located in the human X chromosome, was initially described with three exons transcribing RNA from which the protein MeCP2 was translated. It is now known to have four exons from which two isoforms are translated; however, there is also evidence of additional functional genomic structures within MECP2, including exons potentially transcribing non-coding RNAs. Accompanying the recognition of a higher level of intricacy within MECP2 has been a recent surge of knowledge about the structure and function of human genes more generally, to the extent that the definition of a gene is being revisited. It is timely now to review the published and novel functional elements within MECP2, which is proving to have a complexity far greater than was previously thought.|Genome, Human[MESH]|Humans[MESH]|Methyl-CpG-Binding Protein 2/*genetics/*physiology[MESH]|Regulatory Elements, Transcriptional[MESH] |