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Nhlh2: a basic helix-loop-helix transcription factor controlling physical activity Good DJ; Coyle CA; Fox DLExerc Sport Sci Rev 2008[Oct]; 36 (4): 187-92In mice, targeted deletion of the basic helix-loop-helix transcription factor, nescient helix-loop-helix 2 (Nhlh2), leads to adult-onset obesity and reduced physical activity. We propose the novel hypothesis that transcriptional activity by Nhlh2 (NHLH2 in humans) controls either the ability or the motivation for exercise.|Animals[MESH]|Basic Helix-Loop-Helix Transcription Factors/*genetics/metabolism[MESH]|Gene Deletion[MESH]|Genetic Linkage[MESH]|Humans[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Motivation[MESH]|Motor Activity/*genetics[MESH]|Obesity/genetics[MESH]|Transcription Factors/deficiency/genetics/metabolism[MESH] |
