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Endoplasmic reticulum stress, PrP trafficking, and neurodegeneration Soto CDev Cell 2008[Sep]; 15 (3): 339-341In this issue of Developmental Cell, Rane et al. report a cellular pathway to link PrP(Sc), via ER stress and the activation of a preemptive quality control process, to neurodegeneration in a PrP-dependent manner. This pathway puts together several pieces in the puzzle of the relationship between PrP(Sc) and brain damage and may in part explain the mechanism of prion neurodegeneration.|*Oxidative Stress[MESH]|Animals[MESH]|Endoplasmic Reticulum/*metabolism[MESH]|Mice[MESH]|Models, Biological[MESH]|Nerve Degeneration/*metabolism/pathology[MESH]|PrPSc Proteins/*metabolism[MESH]|Proteasome Endopeptidase Complex/metabolism[MESH]|Protein Transport/physiology[MESH] |
