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lüll Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice Singer A; Adoro S; Park JHNat Rev Immunol 2008[Oct]; 8 (10): 788-801Following successful gene rearrangement at alphabeta T-cell receptor (TCR) loci, developing thymocytes express both CD4 and CD8 co-receptors and undergo a life-or-death selection event, which is known as positive selection, to identify cells that express TCRs with potentially useful ligand specificities. Positively selected thymocytes must then differentiate into either CD4(+) helper T cells or CD8(+) cytotoxic T cells, a crucial decision known as CD4/CD8-lineage choice. In this Review, we summarize recent advances in our understanding of the cellular and molecular events involved in lineage-fate decision and discuss them in the context of the major models of CD4/CD8-lineage choice.|Animals[MESH]|CD4-Positive T-Lymphocytes/*immunology/metabolism[MESH]|CD8-Positive T-Lymphocytes/*immunology/metabolism[MESH]|Cell Lineage[MESH]|Cytokines/immunology/metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|Protein Kinases/metabolism[MESH]|Receptors, Antigen, T-Cell/*immunology/metabolism[MESH]|Signal Transduction[MESH]|Thymus Gland/cytology/*immunology/metabolism[MESH]|Transcription Factors/metabolism[MESH] |