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Shouts, whispers and the kiss of death: directional secretion in T cells Huse M; Quann EJ; Davis MMNat Immunol 2008[Oct]; 9 (10): 1105-11T cells use secreted soluble factors for highly specific intercellular communication and targeted cell killing. This specificity is achieved first through T cell receptor-mediated recognition of complexes of peptide and major histocompatibility complex displayed by appropriate antigen-presenting cells and then by the directed secretion of cytokines and lytic factors into the immunological synapse between the T cell and antigen-presenting cell. Studies have begun to probe the molecular basis for this synaptic secretion and have also shown that T cells release chemokines and certain inflammatory factors through a multidirectional pathway directed away from the synapse. Thus, the mode of secretion seems to be tailored to the intended function of the secreted molecule.|Animals[MESH]|Antigen Presentation/*immunology[MESH]|Antigen-Presenting Cells/*immunology[MESH]|Cell Communication/*immunology[MESH]|Cell Polarity[MESH]|Humans[MESH]|Inflammation Mediators/immunology/*metabolism[MESH]|Lymphocyte Activation/physiology[MESH]|Microtubules/immunology/metabolism[MESH]|T-Lymphocytes/*immunology/*metabolism[MESH] |
