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lüll Antigen-presentation properties of plasmacytoid dendritic cells Villadangos JA; Young LImmunity 2008[Sep]; 29 (3): 352-61One of the remaining enigmas of the dendritic cell (DC) network is the potential contribution of plasmacytoid DCs (pDCs) to antigen presentation. Although the antigen-presentation capacity of conventional DCs (cDCs) is clearly defined, pDCs are generally attributed as having little, if any, antigen-presentation function. Instead, pDCs are regarded as immunomodulating cells, capable of directing the immune response through their secretion of large amounts of type I interferons. In this review, we examine the evidence for a potential role of pDC in antigen capture, processing, and presentation to T cells at sites of infection and in the lymph nodes.|*Antigen Presentation[MESH]|Animals[MESH]|Cell Movement[MESH]|Cross-Priming[MESH]|Dendritic Cells/*immunology/physiology[MESH]|Humans[MESH]|Infections/*immunology[MESH]|Lymph Nodes/immunology[MESH]|Lymphocyte Activation[MESH]|Major Histocompatibility Complex/*immunology[MESH]|Peptides/immunology/metabolism[MESH]|T-Lymphocytes/*immunology/metabolism[MESH] |