Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll A role for planar cell polarity signaling in angiogenesis Cirone P; Lin S; Griesbach HL; Zhang Y; Slusarski DC; Crews CMAngiogenesis 2008[]; 11 (4): 347-60The planar cell polarity (PCP) pathway is a highly conserved signaling cascade that coordinates both epithelial and axonal morphogenic movements during development. Angiogenesis also involves the growth and migration of polarized cells, although the mechanisms underlying their intercellular communication are poorly understood. Here, using cell culture assays, we demonstrate that inhibition of PCP signaling disrupts endothelial cell growth, polarity, and migration, all of which can be rescued through downstream activation of this pathway by expression of either Daam-1, Diversin or Inversin. Silencing of either Dvl2 or Prickle suppressed endothelial cell proliferation. Moreover, loss of p53 rescues endothelial cell growth arrest but not the migration inhibition caused by PCP disruption. In addition, we show that the zebrafish Wnt5 mutant (pipetail (ppt)), which has impaired PCP signaling, displays vascular developmental defects. These findings reveal a potential role for PCP signaling in the coordinated assembly of endothelial cells into vascular structures and have important implications for vascular remodeling in development and disease.|*Cell Polarity/drug effects[MESH]|*Neovascularization, Physiologic/drug effects[MESH]|*Signal Transduction/drug effects[MESH]|Adaptor Proteins, Signal Transducing/genetics[MESH]|Animals[MESH]|Blood Vessels/abnormalities/drug effects[MESH]|Caveolin 1/metabolism[MESH]|Cell Line[MESH]|Cell Movement/drug effects[MESH]|Cell Proliferation/drug effects[MESH]|Cyclohexanes/pharmacology[MESH]|Dishevelled Proteins[MESH]|Endothelial Cells/cytology/drug effects[MESH]|Humans[MESH]|Mice[MESH]|Models, Animal[MESH]|Mutation/genetics[MESH]|O-(Chloroacetylcarbamoyl)fumagillol[MESH]|Phosphoproteins/genetics[MESH]|Sesquiterpenes/pharmacology[MESH]|Tumor Suppressor Protein p53/metabolism[MESH]|Wnt Proteins/metabolism[MESH]|Zebrafish[MESH]|beta Catenin/metabolism[MESH] |