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lüll The tectorial membrane: one slice of a complex cochlear sandwich Richardson GP; Lukashkin AN; Russell IJCurr Opin Otolaryngol Head Neck Surg 2008[Oct]; 16 (5): 458-64PURPOSE OF REVIEW: The review is both timely and relevant, as recent findings have shown the tectorial membrane plays a more dynamic role in hearing than hitherto suspected, and that many forms of deafness can result from mutations in tectorial membrane proteins. RECENT FINDINGS: Main themes covered are the molecular composition, the structural organization and properties of the tectorial membrane, the role of the tectorial membrane as a second resonator and a structure within which there is significant longitudinal coupling, and how mutations in tectorial membrane proteins cause deafness in mice and men. CONCLUSION: Findings from experimental models imply that the tectorial membrane plays multiple, critical roles in hearing. These include coupling elements along the length of the cochlea, supporting a travelling wave and ensuring the gain and timing of cochlear feedback are optimal. The clinical findings suggest stable, moderate-to-severe forms of hereditary hearing loss may be diagnostic of a mutation in TECTA, a gene encoding one of the major, noncollagenous proteins of the tectorial membrane.|Animals[MESH]|Cochlea/physiopathology[MESH]|Deafness/*genetics/physiopathology[MESH]|Disease Models, Animal[MESH]|Extracellular Matrix Proteins/*genetics[MESH]|GPI-Linked Proteins[MESH]|Gene Expression Regulation[MESH]|Hearing Loss, Sensorineural/genetics/*physiopathology[MESH]|Hearing/*genetics/physiology[MESH]|Membrane Glycoproteins/*genetics[MESH]|Mice[MESH]|Mice, Transgenic[MESH]|Sensitivity and Specificity[MESH]|Tectorial Membrane/anatomy & histology/*physiology[MESH] |