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lüll Adoptive T-cell immunotherapy of chronic lymphocytic leukaemia Foster AE; Brenner MK; Dotti GBest Pract Res Clin Haematol 2008[Sep]; 21 (3): 375-89Immunotherapy for B-cell chronic lymphocytic leukaemia (B-CLL) and other haematological malignancies may consist of passive antibody, active immunization or adoptive T-cell transfer. This chapter will focus on T-lymphocyte immunotherapy; an approach supported by earlier observations that the beneficial effects of allogeneic stem cell transplantation depend, in part, on the graft-versus-leukaemia effects mediated by these cells. One promising strategy consists of the genetic manipulation of effector T lymphocytes to express tumour-specific T-cell receptors or chimeric antigen receptors directed against surface antigens on the B-CLL cells. This methodology is now being integrated with the concept that tumour recurrence may be due to the persistence of a reservoir of more primitive and chemoresistant tumour cells, dubbed 'cancer stem cells', with self-renewal capacity. Identification and characterization of these cancer stem cells in B-CLL is crucial for the development of new anti-tumour agents, and for the identification of target antigens for cellular immunotherapy. This chapter will describe how immunotherapy may be directed to a more primitive side population of B-CLL cells.|Gene Transfer Techniques[MESH]|Humans[MESH]|Immunotherapy, Adoptive/*methods[MESH]|Leukemia, B-Cell/immunology/pathology/therapy[MESH]|Leukemia, Lymphocytic, Chronic, B-Cell/*immunology/therapy[MESH]|Receptors, Antigen, T-Cell, alpha-beta/genetics[MESH]|Stem Cells/immunology[MESH]|T-Lymphocytes/*immunology[MESH] |