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lüll The alliance of sphingosine-1-phosphate and its receptors in immunity Rivera J; Proia RL; Olivera ANat Rev Immunol 2008[Oct]; 8 (10): 753-63Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is increased in many inflammatory conditions, such as asthma and autoimmunity. Much of the immune function of S1P results from the engagement of a family of G-protein-coupled receptors (S1PR1-S1PR5). Recent findings on the role of S1P in immunosurveillance, the discovery of regulatory mechanisms in S1P-mediated immune-cell trafficking and new advances in understanding the mechanism by which S1P affects immune-cell function indicate that the alliance between S1P and its receptors has a fundamental role in immunity.|Animals[MESH]|Cell Movement[MESH]|Chemotaxis[MESH]|Dendritic Cells/*immunology/metabolism[MESH]|Humans[MESH]|Lymphocytes/*immunology/metabolism[MESH]|Lysophospholipids/immunology/*metabolism[MESH]|Macrophages/*immunology/metabolism[MESH]|Mast Cells/*immunology/metabolism[MESH]|Receptors, Lysosphingolipid/immunology/*metabolism[MESH]|Signal Transduction[MESH]|Sphingosine/*analogs & derivatives/immunology/metabolism[MESH] |