Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll From UVs to metastases: modeling melanoma initiation and progression in the mouse Zaidi MR; Day CP; Merlino GJ Invest Dermatol 2008[Oct]; 128 (10): 2381-91Cutaneous malignant melanoma is highly invasive and capable of metastasizing to distant sites where it is typically resistant to available therapy. While striving to prevent or eradicate melanoma, researchers have two significant advantages not shared by those working on many other cancers. The main environmental etiological agent, UV radiation, is known and melanocytic lesions are excisable for molecular analysis from most stages. Yet knowledge about how UV initiates melanoma has been insufficient to achieve prevention, and the understanding of metastatic mechanisms has been inadequate to reduce mortality. Here, we review the value of melanoma mouse models, focusing on these critical early and late stages.|*Disease Models, Animal[MESH]|*Mice[MESH]|Animals[MESH]|Disease Progression[MESH]|Melanoma/*etiology/pathology/secondary[MESH]|Neoplasms, Radiation-Induced/*etiology/pathology/secondary[MESH]|Skin Neoplasms/*etiology/pathology/secondary[MESH]|Ultraviolet Rays/*adverse effects[MESH] |