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lüll Melanocytes in development, regeneration, and cancer White RM; Zon LICell Stem Cell 2008[Sep]; 3 (3): 242-52The genes required for stem cell specification and lineage restriction during embryogenesis also play fundamental roles in adult tissue regeneration and cancer. This "development-regeneration-cancer" axis is exemplified by the vertebrate pigmentation system. Melanocytes exhibit almost unlimited self-renewal capacity during regenerative processes such as mammalian hair recoloration and zebrafish fin regeneration. Melanoma utilizes many regulatory signals and pathways required during ontogeny and regeneration. A discussion of these interconnections highlights how studies of stem cell function in embryonic and regenerative contexts can yield insights into melanoma biology.|*Regeneration[MESH]|Animals[MESH]|Humans[MESH]|Melanocytes/cytology/*physiology[MESH]|Melanoma/*physiopathology[MESH]|Stem Cells/cytology/physiology[MESH] |