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Temporal organization of the cell cycle Tyson JJ; Novak BCurr Biol 2008[Sep]; 18 (17): R759-R768The coordination of growth, DNA replication and division in proliferating cells can be adequately explained by a 'clock + checkpoint' model. The clock is an underlying cyclical sequence of states; the checkpoints ensure that the cycle proceeds without mistakes. From the molecular complexities of the control system in modern eukaryotes, we isolate a simple network of positive and negative feedbacks that embodies a 'clock + checkpoints'. The model accounts for the fundamental physiological properties of mitotic cell divisions, evokes a new view of the meiotic program, and suggests how the control system may have evolved in the first place.|*Models, Biological[MESH]|Cell Cycle/*physiology[MESH]|Cyclin-Dependent Kinases/physiology[MESH]|Eukaryotic Cells/cytology[MESH] |
