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Pulmonary function tests Behr J; Furst DERheumatology (Oxford) 2008[Oct]; 47 Suppl 5 (ä): v65-7Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the leading cause of morbidity and mortality in SSc patients. In autopsy studies, up to 70% of the SSc patients show histological evidence of lung involvement. In surgical lung biopsies from SSc-ILD patients, a pattern of non-specific interstitial pneumonia is present in a majority, while usual interstitial pneumonia is found in a more variable proportion of patients. Up to 90% of the SSc patients have lung function abnormalities, especially with respect to gas transfer. Pulmonary function testing, therefore, is a major tool of investigation of lung involvement in SSc.|Exercise Test[MESH]|Humans[MESH]|Lung Diseases, Interstitial/*complications/physiopathology[MESH]|Lung/*physiopathology[MESH]|Plethysmography, Whole Body[MESH]|Prognosis[MESH]|Pulmonary Diffusing Capacity[MESH]|Respiratory Function Tests[MESH]|Scleroderma, Systemic/*complications/physiopathology[MESH]|Sensitivity and Specificity[MESH] |
