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lüll Clinical review: treatment of pediatric obesity: a systematic review and meta-analysis of randomized trials McGovern L; Johnson JN; Paulo R; Hettinger A; Singhal V; Kamath C; Erwin PJ; Montori VMJ Clin Endocrinol Metab 2008[Dec]; 93 (12): 4600-5CONTEXT: The efficacy of treatments for pediatric obesity remains unclear. OBJECTIVE: We performed a systematic review of randomized trials to estimate the efficacy of nonsurgical interventions for pediatric obesity. DATA SOURCES: Librarian-designed search strategies of nine electronic databases from inception until February 2006, review of reference lists from published reviews, and content expert advice provided potentially eligible studies. STUDY SELECTION: Eligible studies were randomized trials of overweight children and adolescents assessing the effect of nonsurgical interventions on obesity outcomes. DATA EXTRACTION: Independently and in duplicate, reviewers assessed the quality of each trial and collected data on interventions and outcomes. DATA SYNTHESIS: Of 76 eligible trials, 61 had complete data for meta-analysis. Short-term medications were effective, including sibutramine [random-effects pooled estimate of body mass index (BMI) loss of 2.4 kg/m(2) with a 95% confidence interval (CI) of 1.8-3.1; proportion of between-study inconsistency not due to chance (I(2)) = 30%] and orlistat (BMI loss = 0.7 kg/m(2); CI = 0.3-1.2; I(2) = 0%). Trials that measured the effect of physical activity on adiposity (i.e. percent body fat and fat-free mass) found a moderate treatment effect (effect size = -0.52; CI = -0.73 to -0.30; I(2) = 0%), whereas trials measuring the effect on BMI found no significant effect (effect size = -0.02; CI = -0.21 to 0.18; I(2) = 0%), but reporting bias may explain this finding. Combined lifestyle interventions (24 trials) led to small changes in BMI. CONCLUSIONS: Limited evidence supports the short-term efficacy of medications and lifestyle interventions. The long-term efficacy and safety of pediatric obesity treatments remain unclear.|Anti-Obesity Agents/*therapeutic use[MESH]|Child[MESH]|Data Collection[MESH]|Humans[MESH]|Life Style[MESH]|Motor Activity[MESH]|Obesity/diet therapy/*drug therapy[MESH]|Randomized Controlled Trials as Topic/standards/statistics & numerical data[MESH] |