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Treatment of acute hepatitis C: the success of monotherapy with (pegylated) interferon alpha Wiegand J; Deterding K; Cornberg M; Wedemeyer HJ Antimicrob Chemother 2008[Nov]; 62 (5): 860-5Early control in the acute phase of hepatitis C infection is an attractive therapeutic goal in order to shorten disease duration and infectivity, to prevent chronicity and progression to advanced liver disease and to avoid eventual therapeutic non-response in the later stages of chronic hepatitis C. Over the past decade, different interferon-based treatment options have been developed, which lead to sustained virological response rates of up to 98%. The present article summarizes the successful invention of immediate and delayed strategies in acute hepatitis C monoinfection, critically discusses potential limitations and illustrates the therapeutic challenges of the near future.|Antiviral Agents/*therapeutic use[MESH]|Hepatitis C/*drug therapy[MESH]|Humans[MESH]|Interferon alpha-2[MESH]|Interferon-alpha/*therapeutic use[MESH]|Polyethylene Glycols[MESH]|Recombinant Proteins[MESH] |
